10x Genomics
Chromium Single Cell Immune Profiling

Cell Ranger5.0, printed on 12/03/2024

What is Loupe V(D)J Browser?

Introduction

Loupe V(D)J Browser is a desktop application for Windows and macOS that allows the user to analyze, search, and visualize V(D)J sequences and clonotypes from 5' Chromium Single Cell Immune Profiling data.

Loupe is named after a jeweler's loupe meant for inspecting precious gems.

	10x Chromium	Sequencer	10x Cell Ranger	10x Loupe V(D)J Browser
Cell Suspension	Barcoding & Library Construction	Sequence library	Pipelines	Analysis & Visualization

Using Loupe V(D)J Browser, you can quickly:

• Determine the most common paired alpha and beta TCR chains or heavy and light BCR chains in your sample
• Filter clonotypes based on their antigen specificity or UMI count per antigen
• Examine full-length V, D, and J amino acid and nucleotide sequences to detect variants within V(D)J transcripts
• Search for motifs within CDR3 regions
• Compare clonotype frequencies between samples

To find out how to use Loupe V(D)J Browser to explore your data, start the tutorial.